Cancer: Mammalian Models for Translational Research

R01 (also available: Collaborative R01)

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. This FOA replaces PAR-14-241, “Research Projects to Enhance Applicability of Mouse Models for Translational Research (R01)”.  This FOA continues the goals of PAR-14-241, except that these goals are no longer limited to mouse models but are expanded to cover any mammalian cancer models.

The NCI supports many hypothesis-driven, mechanistic R01 projects that employ mammals, or develop and use mammalian cancer models or transplanted tumor models for many aspects of oncology research. However, the NCI has not previously supported projects devoted to ensuring that mammalian models used for translational research questions are appropriate for those purposes and that the models provide reliable and informative data for patient benefit. Applications to this FOA could propose to overcome limitations of mammalian oncology models, define a new translational use of mammalian models or their genetics for unmet needs, advance standard practices for modeling human cancers and tumors and for validating and credentialing models, or develop widely applicable tool strains or resources that enable cross-species comparisons.

• Pre-Application Submission Deadline: N/A
• Application Submission Deadline: 5:00 PM local time of applicant organization, Feb. 5, 2017

Companion funding opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.