Behavioral Health: Reducing the Duration of Untreated Psychosis

R01 (also available: R34)

Reducing the Duration of Untreated Psychosis in the United States

This Funding Opportunity Announcement (FOA) seeks research project grant applications that test practical, reproducible strategies for substantially reducing the duration of untreated psychosis (DUP) among persons who experience a first episode of psychosis (FEP) by eliminating bottlenecks or closing gaps in the pathway to Coordinated Specialty Care (CSC) services.

Compared to traditional treatment approaches, programs that integrate pharmacologic, psychological, and rehabilitation interventions for FEP, i.e., team-based Coordinated Specialty Care (CSC), have been found to produce a range of positive clinical and functional outcomes. However, the timing of treatment is critical. In the U.S. treatment is typically delayed between one and three years, while the World Health Organization advocates reducing DUP to 3 months or less.


  • Pre-Application Submission: N/A
  • Application Submission: 5:00 PM local time of applicant organization, Mar. 17, 2017; Jul. 18, 2017; Nov. 17, 2017; Mar. 19, 2018; Jul. 18, 2018; Nov. 19, 2018; Mar. 19, 2019

Companion funding opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.