Phenotyping: Using IMPC-Generated Knockout Mouse Strains


In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The KOMP2 KO mouse phenotyping effort has generated 2,500 mouse strains with plans to generate an additional 6,000 over the next five years. Overall, the IMPC hopes to achieve broad-based phenotyping of 20,000 KO strains. About 30% of these strains either are or are expected to be embryonic or perinatal lethal or subviable. A large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in depth phenotyping and research.


  • Pre-Application Submission: 30 days prior to application
  • Application Submission: 5:00 PM local time of applicant organization,
    • June 5, 2017 (new) and July 5, 2017 (renewal, resubmission, revision);
    • October 5, 2017 (new) and November 5, 2017 (renewal, resubmission, revision);
    • June 5, 2018 (new) and July 5, 2018 (renewal, resubmission, revision);
    • October 5, 2018 (new) and November 5, 2018 (renewal, resubmission, revision);
    • June 5, 2019 (new) and July 5, 2019 (renewal, resubmission, revision);
    • October 5, 2019 (new) and November 5, 2019 (renewal, resubmission, revision)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.