Chemical Threats: Enhancing Medical Response Capabilities

PAR-16-128, PAR-16-129, PAR-15-315, PAR-15-146
U01, U54, & R21

The NIH CounterACT program is part of the larger NIH Biodefense program, coordinated by NIAID, which also includes biological and radiation/nuclear threats. The overall program is part of the HHS Public Health Emergency Medical Countermeasures Enterprise (PHEMCE), which coordinates medical countermeasures-related efforts across the Department of Health & Human Services (HHS) and other USG agencies.

The overarching goal of the CounterACT program is to integrate cutting-edge research with the latest technological advances in science and medicine to enhance the nation’s medical response capabilities during chemical emergencies. This is a trans-NIH effort, involving partnerships with the NEI, NIAID, NIAMS, NICHD, NHLBI, NIEHS, NLM, and NINDS to execute the overall NIH Strategic Plan and Research Agenda for Medical Countermeasures Against Chemical Threats.

The NIH has developed a comprehensive CounterACT Research Network that includes Research Centers of Excellence (U54), individual research projects (U01: PAR-16-128 and PAR-16-129), exploratory and developmental translational research projects (R21), SBIR projects, contracts, and Interagency Agreements with the Department of Defense (DoD). The network conducts basic, translational, and preclinical research aimed at the discovery and/or identification of better medical countermeasures against chemical threat agents, and supports their movement through the regulatory process in collaboration with other federal departments, agencies, and initiatives, such as HHS Biomedical Advanced Research & Development Authority (BARDA), FDA Medical Countermeasures Initiative (MCMi), and the Defense Threat Reduction Agency (DoD DTRA).

CounterACT Lead Identification U01 Program Directors/Principal Investigators (PDs/PIs) will become members of the CounterACT research network, and will be able to utilize its resources, such as the CounterACT Preclinical Development Facility (CPDF). They will also be expected to participate in annual meetings of the CounterACT Network to share information and ideas.

For all opportunities: Letter of Intent is due 30 days before application submission due date



Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.