Cancer: Screening Process Research Centers

Feb 9, 2017
UM1 (also available: U24)

Population-based Research to Optimize the Screening Process (PROSPR)

Population-based Research to Optimize the Screening Process (PROSPR) is the National Cancer Institute (NCI) program to promote research aimed at evaluating and improving the cancer screening process. As a part of the reissued PROSPR program, this Funding Opportunity Announcement (FOA) solicits applications for PROSPR UM1 Research Centers. A companion FOA (RFA-CA-16-017) will support a PROSPR U24 Coordinating Center.

The overall goal for PROSPR Research Centers is to enhance understanding of the implementation and effects of screening as practiced in multiple, heterogeneous healthcare environments in the United States. Therefore, the research programs proposed must cover long-term observations of diverse cohorts of patients who are eligible for screening. In addition to observational research to evaluate factors that affect the quality of the screening process for the selected cancer type, these programs should also develop and pilot-test interventions aimed at improving the screening process for that cancer.

It is expected that this FOA will support one PROSPR Research Center for each of the three cancer types: cervical, colorectal, and lung cancer. Each proposed Research Center must be entirely focused on screening for one of these three eligible cancer types.

In addition, PROSPR Research Centers to be proposed must be able to study the cancer screening processes in at least three different healthcare systems. Therefore, appropriate collaborative arrangements with providers of screening/diagnostic services are required.


  • Pre-Application Submission: Jan. 9, 2017
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 9, 2017

Companion Opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.