Alzheimer’s Disease: Understanding the Effects of ApoE2

Feb 10, 2017

Understanding the Effects of ApoE2 on the Interaction between Aging and Alzheimer’s Disease

This FOA invites applications on descriptive, basic and translational studies of APOE2 to delineate the functional effects of ApoE2 on healthy aging of the brain and other tissues. The primary focus is on the “APOE2–Aging-AD” relationship and the mechanistic effects of the protective variant on aging and potential interaction/cross talk between tissues in the aging process and AD.

These studies are expected to generate new mechanistic insights that involve brain and/or other organs and assist in the identification of potential prognostic and diagnostic markers and therapeutic targets for AD and other age-related cognitive disorders. Eventually, the findings from these studies could lead to translational research opportunities not only to prevent or delay the onset of AD, but also to protect against multiple age-related conditions.  


  • Pre-Application Submission: Jan. 10, 2017
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 10, 2017

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.