Alzheimer’s Disease: Research on Decision Making

R01 (also available: R21)

Basic and Translational Research on Decision Making in Aging and Alzheimer’s Disease

This funding opportunity announcement (FOA) invites applications for basic research to better characterize the affective, cognitive, social, and motivational parameters of impaired and intact decision making in both normal aging and Alzheimer’s disease (AD). Research is sought that will characterize the extent to which basic behavioral and neural processes involved in decision-making are differentially impacted in normal aging and AD, investigate the influence of social factors on decision-making, and investigate the decision-making factors that render older adults (with or without cognitive impairment) vulnerable to financial exploitation and other forms of mistreatment and abuse.

The FOA also invites applications to apply basic research on the processes involved in decision-making to the design of decision-supportive interventions for midlife and older adults with and without AD. Specific opportunities include the development of decision-supportive interventions to leverage cognitive, emotional and motivational strengths of these populations; tools to assess decisional capacity; strategies for simplifying choices and offering better defaults; and the promotion of timely adoption of optimal delegation practices (e.g., power of attorney, living wells, etc.). 


  • Pre-Application Submission: N/A
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 5, 2017; Jun. 5, 2017; Oct. 5, 2017; Feb. 5, 2018; Jun. 5, 2018; Oct. 5 2018; Feb. 5, 2019; Jun. 5, 2019; Oct. 5, 2019

Companion funding opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.