Alzheimer’s Disease: Relationship of Delirium, AD, & Dementias

R01 (also available R21/R33)

Clarifying the Relationship between Delirium and Alzheimer’s Disease and Related Dementias

This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer’s disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium.

Relevant research projects may focus on, but are not limited to, those that

  • Provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium,
  • Elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models,
  • Identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa,
  • Diagnose and assess one condition in the setting of the other,
  • Identify putative phenotypes of patients with co-existing ADRD and delirium, or
  • Test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa.

Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.


  • Pre-Application Submission: N/A
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 5, 2017; Jun. 5, 2017; Oct. 5, 2017; Feb. 5, 2018; Jun. 5, 2018; Oct. 5 2018; Feb. 5, 2019; Jun. 5, 2019; Oct. 5, 2019

Companion Opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.