AIDS/Cancer: Understanding Non-AIDS-defining or AIDS-defining Cancers

R01 (also available: R21)

The purpose of this funding opportunity announcement (FOA) is to continue advancing our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying human immunodeficiency (HIV) infection or acquired immunodeficiency syndrome (AIDS), particularly the non-AIDS defining malignancies which are now a leading cause of death in HIV-infected individuals.  

This FOA encourages high or medium priority AIDS research in areas such as the study of the etiologic factors, cofactors, immunopathogenesis, diagnosis, and consequences of both non-AIDS defining and AIDS-defining malignancies in populations with an underlying HIV infection. 

This FOA encourages research efforts that will

(i) identify specific contributions resulting from HIV infection and its potential interaction with other pathogens for the development and pathogenesis of these cancers and

(ii) provide information on the clinical outcomes of such cancers in the HIV-infected population.

Ultimately, such efforts could inform screening approaches and therapies targeted to the HIV-infected population.   


  • Pre-Application Submission: N/A
  • Application Submission: 5:00 PM local time of applicant organization, Jan. 7, 2017; May 7, 2017; Sep. 7, 2017; Jan. 7, 2018; May 7, 2018; Sep. 7, 2018; Jan. 7, 2019; May 7, 2019; Sep. 7, 2019

Companion funding opportunity:


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.