Alzheimer’s Disease: Systemic or Non-Neuronal Systems


Dynamic Interactions between Systemic or Non-Neuronal Systems and the Brain in Aging and in Alzheimer’s Disease

This FOA encourages research projects on the role of aging-related changes in systemic, peripheral, and/or non-neuronal factors – individually or in combination – to the pathogenesis, presentation, and/or progression of Alzheimer’s disease (AD). The goal of this FOA is to support innovative multidisciplinary research that will integrate the AD science with the basic biology of aging and clinical aging research. Successful studies may identify critical processes and pathophysiological pathways to inform novel prevention or intervention strategies for AD and other dementias of aging. Successful applications will likely involve a broad range of expertise including the biology of aging, geriatrics/gerontology, neurodegenerative diseases, and other clinical and translational specialties focused on systemic diseases or specific tissue/organ pathophysiology to identify interrelationships among peripheral systems and the brain.   


  • Pre-Application Submission: N/A
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 5, 2017; Jun. 5, 2017; Oct. 5, 2017; Feb. 5, 2018; Jun. 5, 2018; Oct. 5 2018; Feb. 5, 2019; Jun. 5, 2019; Oct. 5, 2019

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.