Kidney Disease: Polycystic Kidney Disease


This Funding Opportunity Announcement (FOA) is to increase investigator interest in basic and applied investigations of the etiology and pathogenesis of Polycystic Kidney Disease (PKD), in both its autosomal dominant and autosomal recessive forms.  The ultimate aim is to facilitate PKD-related research studies, which will provide the basis for new therapeutic approaches.

It is the intent of this FOA to invite applications from investigators with diverse scientific interests, who wish to apply their expertise into basic and applied research to enhance the understanding of the etiology and pathogenesis of both ADPKD and ARPKD; the genetic determinants and cellular and molecular mechanisms which disrupt normal kidney function; the mechanisms of cyst formation and growth at the cellular and molecular levels; the development of experimental model systems; the development of innovative regenerative approaches; the enhancement of imaging methods or other biomarkers to assess cyst growth and disease progression; and research studies aimed at the identification of therapeutic opportunities and gene targeted strategies to prevent progressive chronic kidney disease due to this disorder.


• Pre-Application Submission: N/A
• Application Submission: 5:00 PM local time of applicant organization, Feb. 5, 2017; Jun. 5, 2017; Oct. 5, 2017; Feb. 5, 2018; Jun. 5, 2018; Oct. 5 2018; Feb. 5, 2019


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.