Kidney Disease: Long-term Kidney Transplantation Outcomes

Deadline
Feb 24, 2017
OPPORTUNITY NO.
RFA-DK-16-025
MECHANISM
U01
RESEARCH AREA(S)
SYNOPSIS

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Centers 

This Funding Opportunity Announcement (FOA) invites cooperative agreement applications to establish a multi-center, multi-disciplinary group of investigators to be known as the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO). 

The APOLLO Network will design and conduct studies of a prospective longitudinal cohort to determine the impact of APOL1 genetic variants as susceptibility factors in US kidney transplant recipients who received kidneys from African American donors.  In addition, the consortium will follow the course of African American kidney donors.  Primary outcomes are the rate of change of kidney function in recipients, and rates of acute rejection of the kidney transplant, graft failure, and return to maintenance dialysis rates in the recipients. Outcomes, including vital and renal functional status, in donors will be assessed to the greatest extent possible.

This FOA invites applications for the APOLLO Network Clinical Centers (CCs) and runs in parallel with a separate FOA that invites applications for the APOLLO Network Scientific Data Research Center (SDRC) (RFA-DK-16-024).

Deadlines:

  • Pre-Application Submission: Jan. 24, 2017
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 24, 2017

Companion Opportunity:

ELIGIBILITY

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.