BRAIN Initiative Cell Census Network (BICCN)

Deadline
Multiple
OPPORTUNITY NO.
RFA-MH-17-210, RFA-MH-17-215, RFA-MH-17-225, & RFA-MH-17-230
MECHANISM
U01, U19, & U24
RESEARCH AREA(S)
SYNOPSIS

BRAIN Initiative Cell Census Network (BICCN):

The BRAIN initiative cell census program is looking to establish the BICCN for a systematic generation of reference cell census data and relevant tools. The overarching goals of the BICCN are to ultimately:

  • generate a comprehensive 3D common reference mouse brain cell atlas that integrates molecular, anatomical, and physiological annotations of brain cell types, and
  • generate reference atlases of brain cells from human and/or non-human primate brain samples.

The expected outcomes of the BICCN include:

  • fundamental knowledge on diverse cell types and their three dimensional organizational logic in the brain;
  • an open-access 3D digital brain cell reference atlas with molecular, anatomical, and physiological annotations of brain cell types in mouse;
  • a comprehensive neural circuit diagram in mouse brain; 
  • reagents for cell-specific targeting;
  • validated high throughput and low cost approaches to characterizing cell diversity in human and/or non-human primate brain samples.

The BICCN will be composed of a group of Centers and Collaboratories supported via four companion FOAs:

 

ELIGIBILITY

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.