Aging: Physical Resilience to Predict Healthspan in Mice

Deadline
Feb 2, 2017
OPPORTUNITY NO.
RFA-AG-17-040
MECHANISM
R01
RESEARCH AREA(S)
SYNOPSIS

Short-term Measurements of Physical Resilience as a Predictor of Healthspan in Mice 

This Funding Opportunity Announcement (FOA) invites applications to develop short-term tests that provide a comprehensive measure of resilience in animal models used in aging studies. Resilience is defined here as the ability of an organism to respond to physical challenges or stresses and return to homeostasis. Increased resilience is believed to correlate with longevity and a longer health-span, but appropriate methodology to test this comprehensibly in animal models is currently lacking.

The purpose of this FOA is to develop appropriate tests to measure resilience to physical, molecular and cellular stresses, as a prelude to being able to predict, using a panel of standardized short-term tests in young or middle-aged animals, whether interventions might lead to improved future health outcomes and longevity.

Deadlines:

  • Pre-Application Submission: Jan. 2, 2017
  • Application Submission: 5:00 PM local time of applicant organization, Feb. 2, 2017

ELIGIBILITY

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.